Department of Genetics, School of Medicine, and Yale Center for Excellence in Genome Science (CEGS), Yale University, New Haven, CT, as a scientist working with Dr. Sherman Weissman, a member of NAS USA, the Director of Molecular Oncology and Development, and Dr. Michael Snyder, the Directors of Yale CEGS (Center of Excellence in Genomic Science). His current interests are:
 

• Further perfected GADAV (Global Analysis of DNA Allelic Variation) developed by Xinghua Pan and applying it to screen the RNA editing spectrum with cDNA pool derived from Apobec1 (a RAN editing enzyme) knockout mouse.
• Developed a new generation of method for Whole Genome Amplification (WGA), sensitive to heterozygous or subtle (< 1kb) chromosomal aberrations (CNV), and to sub-fentogram DNA or single cell/bacteria, without non-specific products and with high ratio as well as sequence fidelity.
• Developed a new technique for transcriptome mRNA amplification in full length from nanagram and sub-nanagram of cDNA, with high ratio fidelity and high efficiency, analyzing on microarray and massively parallel sequencing;
• Developing a new method for genome-wide profiling of DNA methylation from limited amount of DNA/cells, Delta-CpG methylation recovery combining with Solexa sequencing /microarray analysis.
• Developing a method for genome-wide profiling for histone modifications from a few limited number and finally from a single cell.
• Studying the genomic or/and epigenomic mechanism of cancers or/and stem cells from very limited number cells or a single cell using the high-throughput platforms.