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Xunbin Wei |
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Fudan University, China |
| Biography: |
- 1993-1999 Ph.D., Biological Sciences, University of California, Irvine, USA Thesis: Studying T cells at the single cell level with imaging methods Beckman Laser Institute & Medical Clinic, University of California, Irvine Mentors: Dr. Bruce Tromberg and Dr. Michael Cahalan
- 1988-1993 Bachelor of Science, Physics (Laser Technology), University of Science & Technology of China, Hefei, China.
Research Interests and Activities:
- Study and Treat Dermatological Diseases with Laser/Imaging Technologies
- Study Hematology/Cancer with Imaging Technologies
- Study Immunological Diseases with Imaging (Confocal/Two-photon Microscopy) We are developing cutting-edge optical and imaging techniques and applying them to the study of biological processes in vivo at the single cell and the molecular level. Most of our current understanding of biology and medicine comes from studies of cell lines grown in vitro, or from histologically processed tissue. Although they have provided valuable insights, the conclusions made from the in vitro or ex vivo studies need to be further explored in animal models or in vivo. We are directly visualizing those cellular processes in situ where cells are interacting with their natural environment in live animals. The optical imaging techniques used to realize this “in vivo microscopy” include real-time multi-photon fluorescence microscopy, confocal microscopy and near-infrared cellular imaging. Our current biomedical interests include cancer metastasis, the interactions of leukocytes with endothelial cells of the blood vessels under physiological or pathological conditions, and the stem cell biology and regenerative medicine. An “in vivo flow cytometer” is currently being developed to study those processes quantitatively. Other optical means, including FRAP (Fluorescence Recovery After Photobleaching) and FRET (Fluorescence Resonance Energy Transfer), are coupled with the “in vivo microscopy” to study the biological processes in vivo and in real time.
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