Michael Q. Zhang
University of Texas at Dallas
Title : Modeling Dynamics of Cell-fate
Abstract :

Understanding the principles of cell-fate determination and dynamics is fundamentally important in quantitative biology of development and differentiation in metazoans. Exploring general rules of the interplay between gene regulation networks and cell-cell communication/tissue environment can provide valuable insight to the mechanism of cell-fate maintenance or changes. I will describe our recent works with two examples: one is to model the dynamics of iPSC reprogramming by Yamanaka factors or epigenetic perturbation; another is to model the dynamics of cancer stem cells.

Biography :

Dr. Zhang is currently Cecil H. and Ida Green Chair Professor, Director of Center for Systems Biologyat the University of Texas at Dallas. He got B.S. in Mech Eng. from USTC in 1981 and Ph.D. in Statistical Physics from Rutgers U. in 1987.After3-year postdoctoral research in Applied Math at Courant Inst.,he joined CSHL and became full professor in 2002. He spent nearly 20 years in CSHL, running a Computational Genomics lab., teaching in Watson School of Biological Sciences and directing the bioinformatics cancer core facility before moving to Dallas in 2010. He is also a “QianRen” guest professor of Tsinghua U. and an adjunct professor of CSHL and Stony Brook U. He serves in several international scientific advisory boards, including Max Planck Group and Chinese Academy of Sciences. He is one of the world leading scientists in bioinformatics and computational biology. He is the co-Editor-in-Chief of Quantitative Biology and his main research interest is in bioinformatics and computational biology.


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