• Prof. Chung Hsuan (Winston) Chen
  • Prof. Chung Hsuan (Winston) Chen
  • The Genomics Research Center, Academia Sinica, Chinese Taipei
  • Title: Novel Mass Spectrometry Technology Development for Biomarker Discovery and Disease Diagnosis
  • Abstract: Recently, we have developed a few novel mass spectrometry technologies which can be used for detecting bioparticles such as antibodies, cells and virus. We expand the mass range by 10 orders of magnitude to reach to 1017 Daltons. These technologies include (1) Cell mass spectrometry (2) Biomolecular ion accelerator, (3) portable biological mass spectrometer and (4) Single large biomolecular ion detector. Cell mass spectrometer extends the mass region to be covered from 1 megadalton to 1016 Da. Biomolecular ion accelerator increases the singly charged molecular ion energy to mega volts region. This is the first biomolecular ion accelerator in the world. Secondary ion conversion was used to achieve single large bio-molecular ion detection. A single ion with mass-to-charge ratio (M/Z) higher than 10,000,000 was successfully detected. With our novel mass spectrometry technologies, we developed new platforms for disease biomarker discovery. They include (1) discovery of lung cancer biomarkers from exhaled air (2) glycoproteomic platform for discovery of pancreatic cancer biomarkers (3) discovery of biomarkers for pancreatic and gastric cancer. More details on the approach and therapeutic applications will be presented in the meeting.
  • Biography: EDUCATION AND POSITIONS HELD:
    Ph.D., Chemistry, University of Chicago, 1974
    Postdoctoral Fellow, Oak Ridge National Laboratory, 1974-1976
    Research Scientist, Oak Ridge National Laboratory, 1976-1989
    Senior Scientist & Project Leader, Oak Ridge National Laboratory, 1989-2005
    Adjunct Professor, Department of Physics and Astronomy, Vanderbilt University, 1990-2005
    Adjunct Professor, Department of Physics, University of Tennessee, Knoxville, 1993-2005
    Research Fellow and Key Technology Division Head, Genomics Research Center; Academia Sinica, 2005-2006
    Distinguished Research Fellow and Acting Director, Genomics Research Center; Academia Sinica, 2006-2007
    Director, Genomics Research Center, Academia Sinica, 2007-present
    HONORS:
    R & D-100 Award (top 100 Inventions of the year):
    Rare Gas Atom Counter, 1984
    Crystal Laser Beam Monitor, 1987
    Non-CFC Freon Leak Detector, 1992
    Editorial Board: Rapid Communication in Mass Spectrometry
    American Physical Society Fellow, 1995
    Advancement of Outstanding Scholarship Award, 2004-2009
    Fellow, American Association for the Advancement of Science (AAAS, USA), 2009
    Academician, Academia Sinica, 2010
    RESEARCH INTERESTS:
    Chemical Physics and its application in technology development

    Research work in Chen laboratory covers a broad spectrum of atomic, molecular and solid state physics as well as their applications in ultra-sensitive detection technology development. The major research interests are listed in the follows:

    Genomic and Proteomic Technology
    Biomolecular Mass Spectrometry
    Microarray hybridization detection
    DNA typing for forensic applications
    Instrumentation Development for Ultra-low Level Pollutants Detection
    Nanoscience for biomedical applications
    High Temperature Superconductors
    Atomic and Molecular Spectroscopy
    Crossed Molecular Beam for Reaction Dynamics Studies
    Kinetics of F-centers and Self-trapped Excitons in Alkali Halide Crystals
Registration
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Important Dates
Conference:
September 18-20, 2015
Abstract Submission Due:
April 17, 2015  >> May 29, 2015
Early Bird Registration due for Accepted Paper or Abstract: 10 days after acceptance notification

Early Bird Registration due for Audience: July 17, 2015
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Sponsors
武汉大学
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  • 1000Thinktank

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Past Proceedings: iCBBE 2014
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