KeyNote Speaker Details

Prof. Chung Hsuan (Winston) Chen
The Genomics Research Center, Academia Sinica, Chinese Taipei

Title:

Novel Mass Spectrometry Technology Development for Biomarker Discovery and Disease Diagnosis

Abstract:

Recently, we have developed a few novel mass spectrometry technologies which can be used for detecting bioparticles such as antibodies, cells and virus. We expand the mass range by 10 orders of magnitude to reach to 1017 Daltons. These technologies include (1) Cell mass spectrometry (2) Biomolecular ion accelerator, (3) portable biological mass spectrometer and (4) Single large biomolecular ion detector. Cell mass spectrometer extends the mass region to be covered from 1 megadalton to 1016 Da. Biomolecular ion accelerator increases the singly charged molecular ion energy to mega volts region. This is the first biomolecular ion accelerator in the world. Secondary ion conversion was used to achieve single large bio-molecular ion detection. A single ion with mass-to-charge ratio (M/Z) higher than 10,000,000 was successfully detected. With our novel mass spectrometry technologies, we developed new platforms for disease biomarker discovery. They include (1) discovery of lung cancer biomarkers from exhaled air (2) glycoproteomic platform for discovery of pancreatic cancer biomarkers (3) discovery of biomarkers for pancreatic and gastric cancer. More details on the approach and therapeutic applications will be presented in the meeting.

Biography:

EDUCATION AND POSITIONS HELD:
Ph.D., Chemistry, University of Chicago, 1974
Postdoctoral Fellow, Oak Ridge National Laboratory, 1974-1976
Research Scientist, Oak Ridge National Laboratory, 1976-1989
Senior Scientist & Project Leader, Oak Ridge National Laboratory, 1989-2005
Adjunct Professor, Department of Physics and Astronomy, Vanderbilt University, 1990-2005
Adjunct Professor, Department of Physics, University of Tennessee, Knoxville, 1993-2005
Research Fellow and Key Technology Division Head, Genomics Research Center; Academia Sinica, 2005-2006
Distinguished Research Fellow and Acting Director, Genomics Research Center; Academia Sinica, 2006-2007
Director, Genomics Research Center, Academia Sinica, 2007-present
HONORS:
R & D-100 Award (top 100 Inventions of the year):
Rare Gas Atom Counter, 1984
Crystal Laser Beam Monitor, 1987
Non-CFC Freon Leak Detector, 1992
Editorial Board: Rapid Communication in Mass Spectrometry
American Physical Society Fellow, 1995
Advancement of Outstanding Scholarship Award, 2004-2009
Fellow, American Association for the Advancement of Science (AAAS, USA), 2009
Academician, Academia Sinica, 2010
RESEARCH INTERESTS:
Chemical Physics and its application in technology development

Research work in Chen laboratory covers a broad spectrum of atomic, molecular and solid state physics as well as their applications in ultra-sensitive detection technology development. The major research interests are listed in the follows:

Genomic and Proteomic Technology
Biomolecular Mass Spectrometry
Microarray hybridization detection
DNA typing for forensic applications
Instrumentation Development for Ultra-low Level Pollutants Detection
Nanoscience for biomedical applications
High Temperature Superconductors
Atomic and Molecular Spectroscopy
Crossed Molecular Beam for Reaction Dynamics Studies
Kinetics of F-centers and Self-trapped Excitons in Alkali Halide Crystals

Important Dates

Conference:
September 18-20, 2015

Abstract Submission Due:
April 17, 2015 >> May 29, 2015

Early Bird Registration due for Accepted Paper or Abstract: 10 days after acceptance notification

Early Bird Registration due for Audience: July 17, 2015

Email: submit@icbbe.org

Tel : +86 - 132 6470 2230