Yue Ge
US Environmental Protection Agency, RTP, NC 27711, USA
Title : Environment and Human Health: Integrating Scientific Developments into Practical Environmental Applications for the Improvement of Human Health
Abstract :

The simplest way to assess the environmental pollution status is to carry out chemical analysis of air, water, soil, biological extracts and other environmental samples. However, the natural environment contains more than 10000 synthetic chemicals generated from industry, agriculture, transport and other human activities. These environmental chemicals pose a potential threat to human health and make meaningful assessment of their toxic effects a big challenge as well. The complexities of these chemicals can be increased further by processes acting on chemicals once in the environment. Given the large number and complexity of environmental chemicals or pollutants, chemical analysis alone may not offer meaningful assessment of the pollution status of a particular ecosystem, and complex environmental pollution problems can not be solved either by modern environmental engineering or technology alone. Integration of a variety of environmental sciences including basic environmental research, environmental engineering, ecology, and management on social and economic activities will provide effective solutions to complex environmental problems. My presentation will focus on the development of advanced biological approaches and tools especially environmental OMICS (primarily proteomics) and bioinformatics methodologies, and their applications to analysis of animal and human samples exposed to a variety of environmental chemicals for a better understanding of toxic mechanisms and for screening, categorizing, prioritizing and toxicity testing of environmental chemicals. In addition, I will also discuss their possible use in monitoring environmental pollution and detecting the effects of environmental pollution on human health. Some typical examples on integration of environmental science and technology into practical applications to human health risk assessment will be presented.

Biography :

Yue received his Ph.D. in Proteomics at the University of Michigan, Ann Arbor, USA, where he investigated biological mechanisms of Duchenn Muscular Dystrophy by identifying and characterizing protein targets, biomarkers and signaling pathways associated with the disease using functional proteomic approaches. Prior to his Ph.D. studies, he had worked in Walther Oncology Center, Indiana University for four years. His research focused on identification of gene mutations and genetic polymorphisms associated with hypertension, and characterization of cytokine gene expression in human stem and progenitor cells for gene therapy. Following completion of his Ph.D. studies, Yue moved to Department of Proteomics at Invitrogen Inc., where he worked as a lead scientist to develop proteomics technologies and to identify breast cancer biomarkers using the Multiplexed Proteomics Technology Platform built within the research team. As a project leader for bioassay development, Yue also developed many quantitative protein assays for the detection and quantification of disease biomarkers. His work resulted in two patents and a series of bioassays that are being wildly used in biomedical research. After that, Yue took the position of Principal Investigator at US Environmental Protection Agency to lead environmental proteomics research. His laboratory is working in the emerging field of toxicoproteomics. Utilizing improved toxicoproteomic technologies developed by his research team and others to decipher mechanisms and modes of action of chemical-induced carcinogenesis and identify protein biomarkers of exposure, toxicity and effect have been his major research interests. To date, he has published about 25 peer-reviewed scientific papers and 40 abstracts that have been presented in national and international conferences. With regard to service to the broader scientific community, Yue has served as the chair for several international conferences such as 2007 American Electrophoresis Society Annual Meeting, 2008 SETAC European Meeting, and 2008 SETAC World Congress. He has also been an invited speaker for many national and international scientific conferences. As for editorial service, he has consistently reviewed scientific manuscripts s for several proteomics and environmental science journals such as “electrophoresis”, “Proteomics”, “Journal of Proteome Research”, “Oxford Genomics and Proteomics”, “Journal of Environmental Toxicology and Chemistry”, and “Toxicology Letters.”

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